Endocrine Abstracts

We are conducting an open study on the treatment of Graves’ disease (GD) and thyroid-associated ophthalmopathy (TAO) with the monoclonal antibody to CD-20, rituximab (RTX) (MabThera, Hoffman-Roche, Basel). RTX induces depletion of B cells and GD is typically a B cell dependent autoimmune disease. We present preliminary results on 7 patients with GD and TAO at different clinical stages: 3 women with newly diagnosed GD and initial TAO; 1 woman with GD and moderate-severe TA...

BAFF, a member of the TNF family, promotes autoantibody production by increasing B cell survival and proliferation. We have previously shown that serum BAFF concentrations are increased in GD patients. In the present work, we studied the expression of BAFF and BAFF-R, by immunohistochemistry (IHC) on paraffin embedded sections of: 1. orbital adipose tissue from 22 patients (5 men, 17 women) with GO (3 of them with active GO) associated with GD or Hashimoto thyroiditis in 19 an...

Introduction: Familial adenomatous polyposis (FAP) is a dominantly inherited disease characterized by colorectal adenomas, extracolonic gastrointestinal manifestations and extraintestinal diseases. Among them, differentiated thyroid cancer (DTC) is considered very frequent with an approximately risk 160 times higher than in general population, and with a prevalence of the cribriform-morular variant. As this esteem comes from scattered data, we evaluated in a prospective contro...